On the People 250 (not S 250, although the concepts are the same), I remove the ten screws that hold the front cowl to the other body panels, unplug the turn indicators, and remove the cowl and set it aside.
I then open the radiator cap, and add coolant, if there is not coolant all the way to the top of the cap. Then, I start the engine. As the engine warms, and the thermostat opens, coolant circulates through the entire system, and air bubbles will come up into the radiator, and eventually out the filler cap. This causes the fluid level to drop, so I again add coolant.
One can only do this so long before the whole system gets so hot as to splash out coolant, and not just air. At that point, I shut off the engine, and let it cool, and repeat the process.
I imagine if you wanted to drain all the coolant, disconnecting the big hose at the bottom right that connects to the impeller, and very briefly running the engine (w/radiator cap open) would quickly drain most of it.
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