Ihave a Grand Vista and do many all day rides. However, I have modified the seat so I am able to sit back an additional 2 inches. Huge difference in comfort. My wife rides with me but her tolerance level gives out at about the one hour time frame. She does bounce around a lot and being higher, the wind impacts her (I am behind my windshield). The larger tires on some of the models may smooth out the ride a bit. If I were to do it all over again, I would go directly to the Downtown 300. Better all around comfort and no problem at speed for longer rides. Pricey, but that is just the initial investment. My GV gets approx. 60 MPG city, 65 plus on freeway driving. I think the 300 would be fairly comparable to that (check the Downtown 300 forum for user MPGs. Whatever you decide, sit on them, test ride them if you are able, and when you buy start with you and the wife doing small rides to find your comfort level. Good luck.